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We seek to develop, optimize, and apply next-generation molecular genetic technologies to understand gene or gene regulatory network function in a variety of disease contexts.

This enables us to identify technological approaches that are specific to unique indications or cell types and those that can be used in large-scale experimentation for surveying all or most of the genome within cells from many different tissues of origin,  all within a single experiment. The knowledge we gain from fundamental research studies can be applied towards the advancement of next-generation therapeutics and the creation of unique cell-based disease models.  

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To achieve these goals, we use a variety of technologies including:

transgene delivery (mRNA, transposons, lenti/retrovirus), CRISPR, RNAi, synthetic genes engineering cellular circuits, multiparameter flow cytometry, next-generation genome sequencing, and bioinformatic analyses.

 

The lab also translates these technologies and fundamental discoveries for clinical application with an emphasis on cell, gene, and nucleic acid-based therapies.