Publications
2023
Guidi R., Wedeles C., Xu D., Kolmus K., Headland S.E., Teng G., Guillory J., Zeng Y.J., Cheung T.K., Chaudhuri S., Modrusan Z., Liang Y., Horswell S., Haley B., Rutz S., Rose C., Franke Y., Kirkpatrick D.S., Hackney J.A., Wilson M.S. (2023) Argonaute3-SF3B3 complex controls pre-mRNA splicing to restrain type 2 immunity. Cell Reports 42(12):113515. doi.org/10.1016/j.celrep.2023.113515
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Tong A-J., Leylek R., Herzner A-M., Rigas D., Wichner S., Blanchette C., Tahtinen S., Kemball C.C., Mellman I., Haley B., Freund E.C., Delamarre L. (2023) Nucleotide modifications enable rational design of TLR7-selective ligands by blocking RNase cleavage. Journal of Experimental Medicine 221(2): e20230341. doi.org/10.1084/jem.20230341
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Gurung H., Heidersbach A., Darwish M., Chan P., Li J., Beresini M., Zill O., Wallace A., Tong A-J., Hascall D., Torres E., Chang A., Lou K., Abdolazimi Y., Moore A., Uche U., Laur M., Notturno R., Ebert P.J.R., Blanchette C., Haley B., Rose C.M. (2023) Discovery of prevalent, clinically actionable tumor neoepitopes via integrated biochemical and cell-based platforms. Nature Biotechnology. Epub ahead of print. doi.org/10.1101/2022.10.27.513529
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Ortiz-Muñoz G., Brown M., Carbone C.B., Pechuan-Jorge X., Rouilly V., Lindberg H., Ritter A.T., Raghupathi G., Sun Q., Nicotra T., Mantri S.R., Yang A., Doerr J., Nagarkar D., Darmanis S., Haley B., Mariathasan S., Wang Y., Gomez-Roca C., de Andrea C.E., Spigel D., Wu T., Delamarre L., Schöneberg J., Modrusan Z., Price R., Turley S.J., Mellman I., Moussion C. (2023) In situ tumour arrays reveal early environmental control of cancer immunity. Nature 618:827-833. doi.org/10.1038/s41586-023-06132-2
Heidersbach A.J., Dorighi K.M., Gomez J.A., Jacobi A.M., Haley B. (2023) A versatile, high-efficiency platform for CRISPR-based gene activation. Nature Communications 14(1):902.
doi:https://doi.org/10.1038/s41467-023-36452-w
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Freund E.C., Haag S.M., Haley B., Murthy A. Optimized Nonviral Gene Disruption in Primary Murine and Human Myeloid Cells. (2023) Methods in Molecular Biology 2618:201-217. doi: 10.1007/978-1-0716-2938-3_15
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Calses P.C., Pham V.C., Guarnaccia A.D., Choi M., Verschueren E., Bakker S.T., Pham T.H., Hinkle T., Liu C., Chang M.T., Kljavin N., Bakalarski C., Haley B., Zou J., Yan C., Song X., Lin X., Rowntree R., Ashworth A., Dey A., Lill J.R. (2023) TEAD proteins associate with DNA repair proteins to facilitate cellular recovery from DNA damage. Molecular & Cellular Proteomics 22(2):100496. doi.org/10.1016/j.mcpro.2023.100496
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2022
Chen H., Durinck S., Patel H., Foreman O., Mesh K., Eastham J., Caothien R., Newman R.J., Roose-Girma M., Darmanis S., Warming S., Lattanzi A., Liang Y., Haley B. (2022) Population-wide gene disruption in the murine lung epithelium via AAV-mediated delivery of CRISPR-Cas9 components. Molecular Therapy - Methods & Clinical Development. 27:431-449. doi.org/10.1016/j.omtm.2022.10.016
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Pribluda A., Daemen A., Lima A.N., Wang X., Hafner M., Poon C., Modrusan Z., Katakam A.K., Foreman O., Eastham J., Hung J., Haley B., Garcia J.T., Jackson E.L., Junttila M.R. (2022) EHMT2 methyltransferase governs cell identity in the lung and is required for KRASG12D tumor development and propagation. Elife (11):e57648. doi.org/10.7554/eLife.57648
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Deng Y., Diepstraten S.T., Potts M.A., Giner G., Trezise S., Ng A.P., Healey G., Kane S.R., Cooray A., Behrens K., Heidersbach A., Kueh A.J., Pal M., Wilcox S., Tai L., Alexander W.S., Visvader J.E., Nutt S.L., Strasser A., Haley B., Zhao Q., Kelly G.L., Herold M.J. (2022) Generation of a CRISPR activation mouse that enables modeling of aggressive lymphoma and interrogation of venetoclax resistance. Nature Communications 13(1):4739. doi.org/10.1038/s41467-022-32485-9
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Oh S.A., Senger K., Madireddi S., Shaw D., Akhmetzyanova I., Ishizuka I.E., Tarighat S., Lo J.H., Shaw D., Haley B., Rutz S. (2022) High efficiency, multiplexed non-viral engineering of human T cells using plasmid donor DNA. Journal of Experimental Medicine. 219(5):e20211530.
doi.org/10.1084%2Fjem.20211530
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Zimmerman-Savill K.M., Lee B.B., Oeh J., Lin J., Lin E., Chung W-J., Young A., Chen W., Mis M., Mesh K., Eastham J., Gnad F., Jiang Z., Stawiski E.W., Haley B., Daemen A., Want X., Koeppen H., Modrusan Z., Martin S.E., Sampath D., Lin K. (2022) Distinct resistance mechanisms arise to allosteric vs. ATP-competitive AKT inhibitors. Nature Communications 13(1):2057. doi.org/10.1038/s41467-022-29655-0
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Tahtinen S., Tong A-J., Himmels P., Oh J., Paler-Martinez A., Kim L., Wichner S., Oei Y., McCarron M.J., Freund E.C., Amir Z.A., de la Cruz C.C., Haley B., Blanchette C., Schartner J.M., Ye W., Yadav M., Sahin U., Delamarre L., Mellman I. (2022) IL-1 and IL-1ra are key regulators of the inflammatory response to RNA vaccines. Nature Immunology 23:532–542. doi.org/10.1038/s41590-022-01160-y
Venkatanarayan A., Liang J., Yen I., Shanahan F., Haley B., Phu L., Verschueren E., Hinkle T.B., Kan D., Segal E., Long J.E., Lima T., Liau N.P.D., Sudhamsu J., Li J., Klijn C., Piskol R., Junttila M.R., Shaw A.S., Merchant M., Chang M.T., Kirkpatrick D.S., Malek S. (2022) CRAF dimerization with ARAF regulates KRAS-driven tumor growth. Cell Reports 38(6):110351. doi.org/10.1016/j.celrep.2022.110351
Carver J., Kern M., Ko P., Greenwood-Goodwin M., Yu X.C., Duan D., Tang D., Misaghi S., Auslaender S., Haley B., Yuk I.H., Shen A. (2022) A ribonucleoprotein-based decaplex CRISPR/Cas9 knockout strategy for CHO host engineering. Biotechnology Progress 38(1):e3212. doi.org/10.1002/btpr.3212
Chang M.T., Shanahan F., Nguyen T.T.T., Staben S.T., Gazzard L., Yamazoe S., Wertz I.E., Piskol R., Yang Y.A., Modrusan Z., Haley B., Evangelista M., Malek S., Foster S.A., Ye X. (2022) Identifying transcriptional programs underlying cancer drug response with TraCe-seq. Nature Biotechnology 40(1):86-93. doi.org/10.1038/s41587-021-01005-3
Senger, K., Akhmetzyanova I., Haley B., Rutz, S., Oh, S. (2022) Plasmid-based donor templates for non-viral CRISPR/Cas9-mediated gene knock-in in human T cells. Current Protocols 2022 2(9):e538. doi.org/10.1002/cpz1.538
Senger K. and Haley B. (2022) Non-viral alternatives to delivery of CRISPR-Cas gene editing components.CRISPR-Cas9 Based Genome Editing for Treating Genetic Disorders and Diseases. CRC Press.183-223. eBook:9781003088516
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Département d'ophtalmologie, Université de Montréal Centre de recherche de l'Hôpital Maisonneuve-Rosemont
Pavillon Claudine D'Amours
5415 Boul. de l'Assomption
Montréal, QC, Canada H1T 2M4
